Our results obtained with a nutritional approach based on a Coriolus versicolor biomass supplementation are relevant to innovative therapeutic anti-inflammatory strategies aimed to minimize consequences associated with neurodegeneration and oxidative stress of cochleovestibular system pathologies including not only MD but also sudden sensorineural hear loss (SSNHL) where it has recently demonstrated a critical role played by NLRP3 inflammasome [41]. Here, NLRP3 is linked to sudden sensorineural hearing loss.