HMOX1 and Menkes disease: As reported in Figure 2 and Figure 3, mushroom supplementation with Coriolus biomass preparation resulted in up-regulation of the inducible isoforms of both Hsp70 and heme oxygenase-1 (HO-1), in lymphocytes (Figure 2a and Figure 3a), a finding observed also in plasma, (Figure 2b and Figure 3b), as compared to untreated group of MD patients.