Independent of age, higher expression of PIAS1 (a key negative regulator of inflammation) but also adipocyte differentiation was observed in PVAT compared to VAT, whereas PIAS1 protein levels were reduced in PVAT of patients with atherosclerotic aortic aneurysms, coronary artery disease, or aortic stenosis. The gene discussed is PIAS1; the disease is coronary artery disorder.