In fact, humans with mutations in the KISS1R gene, or mice with mutations in KISS1 or KISS1R genes, are affected by hypogonadotropic hypogonadism, characterized by deficient production of gonadotropins and sex steroids, which leads to an incomplete sexual maturation [37,38,39,40,41]. This evidence concerns the gene KISS1R and hypogonadotropic hypogonadism.