Recently, the helicase activity of DDX3X was reported to repress the repeat-associated non-AUG translation of GGGGCC repeats in C9ORF72 via direct binding, thereby reducing the aberrant accumulation of dipeptide repeat that might be likely to ameliorate amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) [8]. This evidence concerns the gene C9orf72 and frontotemporal dementia.