DDX3X and colorectal cancer: In addition, the CK1ε/Dvl2/β-catenin axis was shown to be activated upon DDX3X overexpression to increase colorectal cancer invasion and metastasis in an animal model, whereas these effects could be blocked by inhibitors of CK1ε (PF4800567) and β-catenin/TCF signaling (XAV939) [27].