In the mouse model of PD, celastrol (1) improves PD motor symptoms (cylinder task↑ and rotarod performance↑), (2) inhibits neurodegeneration (tyrosine hydroxylase↑) in the substantial nigra and striatum, (3) reduces neuronal apoptosis (Bcl-2↑) in the substantial nigra, and (4) enhances mitophagy (PINK1↑ and DJ-1↑) in the striatum. This evidence concerns the gene TH and Parkinson disease.