Overall, this evidence supports a relevant function of NRG1/ErbB-dependent regulation of synaptic plasticity in hippocampal-dependent learning/memory processes and suggests that a modulation of ErbB signaling might represent a rescue strategy for neuropsychiatric disorders, like autism spectrum disorders, intellectual disabilities, and AD, which display abnormalities in hippocampal-related forms of synaptic plasticity. The gene discussed is EGFR; the disease is Alzheimer disease.