NR2F2 and cardiomyopathy: Overexpression of COUP-TFII impairs substrate utilization of fatty acids and a general reduction of glucose usage, due to altered expression of the glucose transporter Glut-4, the hexokinase 2 and the 6-phosphofructokinase; moreover PGC-1a, a target of COUP-TFII in adipocytes differentiation, is downregulated in cardiomyopathy [17,61,124].