In pancreatic cancer patients COUP-TFII correlates with a worse prognosis and lower survival; in vitro and in vivo experiments revealed that COUP-TFII promotes invasiveness and anchorage-independent growth of PDAC cells, and it plays a fundamental role in neoangiogenesis by directly modulating VEGF-C [163]. This evidence concerns the gene NR2F2 and pancreatic neoplasm.