Whereas an initial report suggested a positive correlation between COUP-TFII and tumor progression, specifically with a worse outcome and lymph node metastasis [95] (who were linked to VEGF-C expression), recent evidence have challenged this idea, suggesting that COUP-TFII may play different roles during breast cancer progression [175,176,177,178,179]. Here, NR2F2 is linked to metastatic malignant neoplasm in the lymph nodes.