COUP-TFII directly induces the expression of miR-21 in TGF-β-treated cells, resulting in the downregulation of SMAD7 whereas it reduces miR-34a [161,162]; hence, modulating miR-21a and miR-34a, COUP-TFII strengthen its action as tumor oncogene and induces EMT in colorectal cancer. The gene discussed is TGFB1; the disease is colorectal cancer.