Expression of COUP-TFII and other nuclear receptors (e.g., LXRβ, RARα, REVERBα) is relatively high in cancer cells tested by high-throughput qPCR; moreover, the receptor forms a cluster with RXRα, HNF4 (α and β) and PPARγ, reflecting known functional associations and is relatively near to ERα, who is implicated in breast cancer progression (see below for details) [138]. This evidence concerns the gene NR2F2 and breast cancer.