First, its expression increases p21/WAF and cyclin D1 delaying the transition trough the G2/M phase [180]; second, COUP-TFII interacts with nucleolin and it is required for the expression of RARB2, a known tumor suppressor [175]; lastly, these results are confirmed by the observation that COUP-TFII is negatively associated with EMT transition induced by TGF-β, and to the resistance to chemotherapy and to changes in E-cadherin and Slug, the latter two being markers of EMT [179]. This evidence concerns the gene TGFB1 and neoplasm.