MPC1 and neoplasm: MPC1 is a regulator of cancer cells metabolism, which together with MCP2 forms a complex capable of regulating pyruvate transport within mitochondria [172]; the reduction of MPC1 mediated by COUP-TFII has a negative impact on mitochondrial pyruvate import and induces the cells to use different intermediate substrates for the TCA cycle and at the same time increases glycolysis, promoting tumor growth and invasion of prostate cancer cells [172].