CHD is a lethal anomaly that occurs in childhood, which can be caused by partial deletion of chromosome 15q [147]; consistent with this observation, COUP-TFII KO mice show diaphragmatic defects similar to the Bochdalek-type hernia phenotype and a frameshift mutation of NR2F2 was recently identified in a patient with CHD [147,148]. Here, NR2F2 is linked to coronary artery disorder.