Animal models of RA have shown the role of annexin A1 in the anti-inflammatory and chondroprotective effects of neutrophil-derived EVs which depend on the interaction with its receptor formyl peptide receptor 2 (FPR2), inducing anabolic responses with TGF-β1 production and deposition of extracellular matrix, as well as chondrocyte protection from apoptosis [62]. The gene discussed is ANXA1; the disease is rheumatoid arthritis.