The cationic adjuvant formulation (CAF) 01 was selected as the “primer” since it has been previously reported that priming with CAF01 + Antigen facilitates a mixed Th1/Th17 response promoting rapid T cell homing to the lungs after airway boosting [7] and that the administration of CAF01 in combination with H56 TB antigen by parenteral route produces early CD4 T cell responses in the lungs after TB infection [5]. The gene discussed is CD4; the disease is tuberculosis.