Collectively, anti-tumor innate and adaptive immune responses in the tumor microenvironment are altered, and several mechanisms including decreased T cell activation and proliferation, induction of anergic T cells, differentiation of Tregs, down-regulation of major histocompatibility complex (MHC) expression and polarization of macrophages to an immunosuppressive M2 phenotype, are prompted by tumor cells [22,26]. The gene discussed is HLA-C; the disease is neoplasm.