CD274 and neoplasm: This is corroborated by the high concomitant expression of PD-L1 in tumor cells and PD-1 in TIL, which was reported in up to 50% of sRCC of any subtype compared to less than 5% of non-sRCC in another retrospective cohort, suggesting that the PD-1/PD-L1 axis is active in sRCC [33].