FOXA2 and hepatocellular carcinoma: It can be transcriptionally activated by EMT suppressor FOXA2 via interacting with β-catenin and triggering β-catenin inhibitory phosphorylation, thereby attenuating Wnt/β-catenin signaling and activating FOXA2 expression, which may form a positive feedback loop and thus regulating HCC metastasis [26].