Another novel lncRNA called lncRNA-AWPPH, which is highly expressed in HCC tissues, as well as in liver metastatic portal vein tumor thrombus (PVTT) tissues, promotes YBX1-mediated activation of SNAIL1 translation and PIK3CA transcription, and activates the PI3K/AKT pathway. The gene discussed is PIK3CA; the disease is neoplasm.