Although our results revealed that the gene expression of IL-6 and TNF-α is causally affected after H2AFJ knockdown and overexpression in the detected cells, further experiments are still needed to clarify the role of HADC3 in regulating H2AFJ activity by a post-translational modification of lysine acetylation and identify if the genomic DNA of IL-6, as well as other related molecules, is recruited as the component of H2AFJ-associated nucleosome in GBM. The gene discussed is IL6; the disease is glioblastoma.