Intriguingly, transcriptional profiling revealed that the gene expression of H2AFJ, but not other H2A histone family members (H2As), was significantly (p < 0.005) upregulated in mesenchymal-type GBM tissues but relatively lower in proneural-type GBM tissues (Figure 1A,B). The gene discussed is H2AJ; the disease is glioblastoma.