Although a more comprehensive mechanism by which H2AFJ regulates the IL-6-NF-κB axis to modulate PMT progression should be further explored in GBM, our findings may be the first to document that the upregulation of H2AFJ, but not of other H2A subfamily members, is associated with the molecular mechanism for PMT progression, which confers TMZ resistance in GBM. This evidence concerns the gene IL6 and glioblastoma.