Similarly, in TCGA cohorts with IDH1 wild-type GBM without glioma CpG island methylation phenotype (G-CIMP), the increased mRNA levels of H2AFJ was significantly (p = 0.034) correlated with a shorter time to new tumor event after patients receiving TMZ, not radiation, therapy (Figure 3H). Here, IDH1 is linked to glioblastoma.