Examination of total Bcl-2 and phosphorylated Bcl-2 (pBcl-2; Ser-70) expressions in CRC cells under TAX or NOC stimulation by Western blotting using specific antibodies showed that TAX and NOC did not alter levels of the total Bcl-2 protein but increased pBCl-2 (Ser-70) protein expression in these cell lines, which was suppressed by adding the PERK inhibitor GSK or JNK inhibitors SP and JNKI (Figure 7B,C). This evidence concerns the gene MAPK8 and colorectal carcinoma.