In the present study, TAX and NOC reduced the viability of four human CRC cells via apoptosis and G2/M arrest, and involvement of PERK and c-Jun N-terminal kinase (JNK) activation leading to increased phosphorylation of the B-cell lymphoma-2 (Bcl-2) protein and disruption of the mitochondrial membrane potential (MMP) is demonstrated herein. Here, MAPK8 is linked to colorectal carcinoma.