For example, miR-105 has been identified as being up-regulated in tumor cells and exosomes derived from breast cancer cells were demonstrated to breakdown vascular endothelial barriers and induce vascular permeability, thereby promoting metastasis by targeting of ZO-1, a component of cell–cell adhesion complexes in endothelial and epithelial cells [17]. This evidence concerns the gene TJP1 and neoplasm.