In gastric cancer (GC), TGF-β was shown to up-regulate miR-577 expression, which in turn targets SDPR, leading to EMT induction [31]; and miR-520c, which was up-regulated in both cell lines and tissues and shown to increase proliferation, migration and invasion of cancer cells through IRF2 targeting [32]. Here, TGFB1 is linked to gastric cancer.