The protective effects of curcumin on kidney damage have been related to the downregulation of profibrotic cytokines, vascular endothelial growth factor (VEGF), TGF-β, connective tissue growth factor (CTGF) and osteopontin, as well as in extracellular matrix proteins, such as fibronectin and collagen IV [132]. This evidence concerns the gene VEGFA and Nephropathy.