The TA isoforms are able to trigger apoptosis by inducing pro-apoptotic target genes shared with p53, pointing to tumor suppressor function, while the ∆N isoforms can act as dominant negative inhibitors of p53 and the TA isoforms of p63 and p73, suggesting an oncogenic role [23,27,28,29]. The gene discussed is TP53; the disease is neoplasm.