MAPK8 and ischemia: Also, Plotnikov and colleagues demonstrated that a specific JNK inhibitor, IQ-1S (11H-indeno [1–b]-quinoxalin-11-one oxime sodium salt), which has a higher affinity for JNK3 compared with its affinity to JNK1/JNK2, showed a neuroprotective effect in models of ischemia in rat [127].