HTT and Alzheimer disease: A study using drug screening in Caenorhabditis elegans nematodes with neuronal expression of human exon-1 huntingtin (128Q) and mutant Htt striatal cells derived from knock-in HD mice, concluded that isoquercetin improved motor functions in acute spinal cord injury, reduced α-synuclein fibrillization, reduced hippocampal neuronal cell death, improved synaptic plasticity, and reversed histopathological hallmarks of AD [112].