Bee bread at 0.5 g/kg/day significantly improved Lee obesity index, TC, LDL, atherogenic index, aortic oxidative stress status (oxLDL and MDA levels), aortic antioxidant enzymes (SOD and GPx activities), and FAS level in HFD-induced obese rats. This evidence concerns the gene SOD1 and obesity due to melanocortin 4 receptor deficiency.