MRC1 and renal cell carcinoma: After treatment with conditioned medium (CM) of ACHN or Caki-1 cells, the M1L-THP-1 and M1L-U937 cells expressed high CD206 (hereinafter referred to as M2L-THP-1 and M2L-U937), indicating that RCC cells can add some M2-type characteristics to M1L-THP-1 and M1L-U937 cells, similar to the property of TAMs (Figure 1A).