The major reasons for statin intolerance have been reported to be statin-associated muscle symptoms (SAMS) and increased CK levels and their temporal association with initiation of statin therapy [28], partially due to solute carrier organic anion transporter family member 1B1 (SLCO1B1) variant alleles [29]. Here, SLCO1B1 is linked to short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome.