Interestingly, myeloid-derived F4/80+ macrophages (i.e., F4/80+ROSA+ cells) were significantly increased (Figure 4E), whereas CD4+IFN-γ+ T cells (Figure 4F) and CD8+IFN-γ+ T cells (Figure 4G) were drastically decreased in EndoMT-involved PDAC tumors, compared with those in tumors derived from Panc 02 alone and Panc 02 plus Endo cell grafts, indicating that EndoMT-derived CAFs indeed orchestrated tumor-infiltrating myeloid-derived cells to facilitate PDAC tumor growth. This evidence concerns the gene CD8A and neoplasm.