APOB and cardiovascular disorder: This is relevant in that non-HDL cholesterol represents a good estimation of the total amount of potentially atherogenic apolipoprotein B-containing lipid fractions (i.e., LDL, lipoprotein-a, intermediate-density lipoprotein, very low-density lipoprotein, and VLDL remnants), and has a well-established role as an independent predictor of cardiovascular disease, even in patients with normal LDL and triglyceride levels [28].