IPA analysis of 270 mutated genes shared by DMBA, MUN, and PhIP treatment with PP2A deficiency in Lgr5+ cells (Figure S5D) revealed 10 top significantly enriched pathways (Figure S5E), including the intestinal tumor metastasis signaling (p-value = 2.12 × 10−57) and Wnt/beta-catenin signaling (p-value = 1.40 × 10−55). Here, PTPA is linked to intestinal neoplasm.