LGR5 and intestinal neoplasm: Interestingly, exposure to different carcinogens, such as DMBA, MNU, or PhIP, when combined with PP2A deficiency in Lgr5+ intestinal stem cells induced tumorigenesis that was dependent on the activation of pathways including Wnt, PI3K, and RAS-MAPK signalings, the common altered pathways revealed by TCGA human intestinal tumor project [14].