It can induce tumour cell apoptosis, the mechanism of which is as follows: it increases intracellular ROS levels and regulates apoptosis-related genes such as c-myc, BCL-2, p53 and caspases. In our study, 2ME and As2O3 were used as HIF-1α inhibitors and ROS inducers to inhibit the proliferation and migration of MG63 cells, to promote the apoptosis of MG63 cells and to induce more ROS accumulation in cells. Here, HIF1A is linked to neoplasm.