mcEDS-CHST14 was originally described as three independent conditions: A rare type of arthrogryposis syndrome “adducted thumb-clubfoot syndrome” [4]; a specific type of EDS “EDS, Kosho type” [5,6]; and a subset of kyphoscoliosis type without lysyl hydroxylase deficiency [7]. The gene discussed is CHST14; the disease is Ehlers-Danlos syndrome.