In contrast, the protein expression of ABCB1 and ABCG2 in multidrug-resistant cancer cells was unaffected by TMP195 for 72 h, indicating that the downregulation of ABCB1 or ABCG2 does not play a significant role in the chemosensitization of multidrug-resistant cancer cells by TMP195. The gene discussed is ABCG2; the disease is cancer.