HMOX1 and osteoarthritis, knee: These findings are in accordance with the overexpression of Nrf2 and HO-1 detected in the cartilage of patients and animals with osteoarthritis [51,52], suggesting that the high expression of the antioxidant/detoxificant proteins detected in the hippocampus of mice with knee osteoarthritis might act as an endogenous protective response against the oxidative stress generated by this pathology.