HMOX1 and osteoarthritis: Therefore, in addition to the well-known positive effects of anti-inflammatory agents, treatment with antioxidant compounds, for example, inducers of nuclear factor erythroid 2-related factor 2 (Nrf2) and/or other enzymes activated by Nrf2, such as heme oxygenase 1 (HO-1), also attenuates the development of osteoarthritis by regulating redox homeostasis [27,28].