Accordingly, the PI3K/Akt/NF-κB and MAPK signaling pathways are activated in the spinal cord and different brain areas, such as the hippocampus and/or prefrontal cortex, of animals with chronic pain [17,18], and their inhibition reduced the development of osteoarthritis and neuropathic pain [19,20]. Here, NFKB1 is linked to osteoarthritis.