In response to hypoxic conditions, tumor cells reprogram protooncogenes (e.g., cellular myelocytomatosis oncogene (c-Myc)), modify signaling pathways (e.g., Phosphoinositide 3-kinase (PI3K/Akt), and activate specific transcription factors (e.g., hypoxia-inducible factor 1 alpha, HIF-1α) [10]. This evidence concerns the gene HIF1A and neoplasm.