In the univariable analysis, increased E/LA strain was associated with increased age, current smoking, the presence of diabetes, coronary artery disease, and chronic heart failure, using of angiotensin converting enzyme inhibitors/angiotensin II receptor blockers, using of β blockers, decreased triglyceride, and increased E/Ea, LAVI, and LVMI. The gene discussed is ACE; the disease is congestive heart failure.