RBMY1A1 and male infertility: Large deletions of AZFb, including PRY1 and PRY2, seem to cause complete meiotic arrest, which leads to male infertility [190], whereas, patients with deletions of all the AZFb genes, except PRY and RBMY, display hypo-spermatogenesis [191]; these data validate RBMY and PRY central importance in male fertility processes [192].