Several possible scenarios have been put forward following their description in mice: (a) direct sensing of cytoplasmic DNA in cGAS/STING expressing cancer cells leading to cancer derived secretion of pro-inflammatory cytokines such as type I IFN that activate tumor associated dendritic cells; (b) irradiated cancer cells produce CDNs which are then transferred to neighboring innate immune cells via tight gap junctions leading to DC activation; (c) exosomal shedding of tumor-derived DNA to target dendritic cells [64]. Here, STING1 is linked to cancer.