Furthermore, in a murine MC38 xenograft model, two strong doses of irradiation (=hypofractionated, 2 × 8 Gy) were significantly more effective at inducing anti-tumor immunity in combination with PD-1 inhibition than a slightly higher overall dose delivered in multiple small fractions (=hyperfractionated, 10 × 2 Gy) [142]. Here, PDCD1 is linked to neoplasm.