The spontaneous development of EAE in C57BL/6 mice and SLE in MRL-lpr/lpr mice, as well as the acceleration of AI reactions after treatment with MOG and DNA, respectively, is characterized by very similar changes in the differentiation of HSCs, which are associated with the onset of abzymes production [14,15,16,17,18,41,42]. This evidence concerns the gene MOG and systemic lupus erythematosus.