JAG1 and cancer: Furthermore, the EMT RT2 PCR profiler demonstrated that cells reseeded on cirrhotic 3D scaffolds, significantly increased the expression of genes involved in differentiation, development, and morphogenesis such as JAG1 and Notch1; growth and proliferation such as TGFβ1 and ZEB1; ECM and cell adhesion with FN1 and CDH2; and motility and cancer EMT-driven aggressiveness with STAT3, FN1, and TGFβ1 (Figure 4E).