Previous studies have suggested that thromboxane A2 receptor (TBXA2R) is involved in the migration and invasion of breast cancer cells [27,28] and that isoprostanes may also regulate the activation of TBXA2R [13].To determine if this signaling pathway was affected by PF1, a Transwell migration study was performed with a specific inhibitor (ifetroban) of TBXA2R [29]. This evidence concerns the gene PHF12 and breast carcinoma.