Together, the results presented in Figure 5 suggested that yolk sac derived Mφ (Mac1/CD11b+ and F4/80+) of proinflammatory (CD80+, iNOS+) and immunomodulatory (CD206+ Arg-1+) phenotypes were significantly increased in the myocardium of infected mice, and SRT1720 shifted the immune balance towards anti-inflammatory/immunomodulatory Mo/Mφ response in Chagas disease. This evidence concerns the gene CD80 and Chagas disease.