SIRT1 and colitis: Indeed, others have shown the beneficial effects of resveratrol (SIRT1 agonist) in decreasing the Mφ migration to pancreas in a mouse model of diabetes [39] and mesenteric lymph nodes and lamina propria in a mouse model of colitis [40], while genetic deletion of SIRT1 resulted in increased Mφ infiltration in the synovial tissues in inflammatory arthritis [41].