As above, splenic Mo/Mφ of all mice, irrespective of infection and SRT1720 treatment, were capable of responding to in vitro stimulation with T. cruzi by 140–230%, 100–240%, and 121–271% increase in TNF-α, IL-6, and H2O2 release, respectively (vs. matched splenic Mo/Mφ without in vitro antigenic stimulation, Figure 4E–G, all ¢¢p < 0.01). Here, IL6 is linked to infection.