In particular, we found cancer cases expression levels in the third and fourth quartiles for MMP9 (65.4% vs. 12.2% of control), MMP10 (64% vs. 16.3% of control), PAI1 (65% vs. 12.5% of control), CA9 (63.8% vs. 11.5% of control), APOE (61.1% vs. 22.6% of control), SDC1 (64.3% vs. 12.9% of control) and ANG (68.9% vs. 0% of control) to be significantly increased compared to control. The gene discussed is SERPINE1; the disease is cancer.