In another study, after an acute glucose load test, HMW adiponectin decreased in patients with normal glucose tolerance tests and those with impaired fasting glucose (fasting blood glucose levels over 100 mg/dL), but there was no change in patients with impaired glucose tolerance (glucose levels of 140–200 mg/dL 2 h after glucose challenge) and diabetes (glucose levels over 200 mg/dL 2 h after glucose challenge). Here, ADIPOQ is linked to diabetes mellitus.