Considering the specialized dysregulation of aspirin on COX-2/PGE2 signaling and then on PI3K/Akt, RAF/MEK/ERK, and NF-κB signaling in its anti-tumor activity [51], we hypothesized perhaps the same mechanism works in the synergistic anti-tumor effect mediated by the combined treatment. The gene discussed is AKT1; the disease is neoplasm.