NFKB1 and malignant colon neoplasm: Given that dysregulation of the NF-κB signaling pathway is a common event in colon cancer, which contributes to tumor initiation and progression by driving expression of pro-proliferative/ anti-apoptotic genes, the inactivation of NF-κB is intended as a new strategy to eliminate colon cancer cells through induction of apoptosis [17].