Interestingly, the majority of the potential interactions were newly generated after amyloid or IL4 treatment, whereas those interactions are mainly lost after 5-HT treatment (Fig 3G, green circles), suggesting that the regulation of progenitor cells (NSCs) by bdnf could be promoted by amyloid or IL4 treatment and suppressed by 5-HT, which is consistent with our hypothesis. The gene discussed is IL4; the disease is amyloidosis.