In both wild-type and APP/PS1dE9 mouse, we could detect BDNF, NTRK2, and p75/NTR expression; however, increased number of GFAP-positive astrocytes AD brains did not correlate with the expression of these proteins, suggesting that BDNF signaling might not regulate NSC proliferation in mouse brains. The gene discussed is NTSR1; the disease is Alzheimer disease.