The enriched KEGG pathways for the upregulated DEGs include cell cycle, DNA replication, Epstein-Barr virus infection, small cell lung cancer, glycosaminoglycan degradation, pyrimidine metabolism, microRNAs in cancer, shigellosis, p53 signalling pathway, purine metabolism and pathways in cancer (Figure 4A). The gene discussed is TP53; the disease is cancer.