Therefore, extensive researches have been conducted on identifying the makers for early HCC, many markers, such as AFP-L3 [24], DCP [25], GPC3 [26, 27], OPN [28], GP73 [29], SCCA [30], annexin A2 [31], suPAR [32], MDK [33], AXL [34], and TRX [35] were screened and undergoing further assessment in phase II studies. This evidence concerns the gene SPP1 and hepatocellular carcinoma.