Given the central role of the CXCL12/CXCR4/CXCR7 axis on BMDCs trafficking and in the pathogenesis of endometriosis, we hypothesized that blocking CXCR4 or CXCR7 in endometriosis using a reproductive and immune‐competent murine model would inhibit the growth of endometriosis. Here, CXCR4 is linked to endometriosis.