Only sex (OR = 9.001, 95% CI: 3.268 ‐ 24.792, P < .001), hepatitis (OR = 0.323, 95% CI: 0.121‐0.860, P = .024), AFP (OR = 0.997, 95% CI: 0.995‐1.000, P = .046), CA199 (OR = 1.016, 95% CI: 1.007‐1.025, P < .001) and ANRI (OR = 0.904, 95% CI: 0.843‐0.969, P = .004) were the independent differential factors for the presence of ICC (Figure 1). This evidence concerns the gene AFP and Hepatitis.