CR improved survival for mice (Masoro, 2005) and 40% CR (Mai et al., 2003), but not 20% CR (Kakuni et al., 2002), reduced the number of polyps in Apc+/Min mice, implicating severe CR as a pro‐longevity intervention that could be combined with ACA to achieve an additive effect on tumor suppression and delaying general aging. This evidence concerns the gene APC and neoplasm.