DNASE1L3 is an endonuclease that mediates the breakdown of DNA during apoptosis.23 Transcriptomic studies described it as an eosinophilic gene and responsive to ICS treatment in induced sputum of subjects with asthma.7, 13, 24 However, there is no further evidence that identifies specific roles of DNASE1L3 in the pathogenesis of asthma. This evidence concerns the gene DNASE1L3 and asthma.