NLRP3 and asthma: 26 IL‐1β is produced mainly by macrophages, cultured bronchial epithelial cells, and neutrophils.27, 28 In those with asthma, the presence of neutrophilia has been associated with frequency of exacerbations,28 poor response to ICS,29, 30, 31 and disease severity.32 Simpson et al33 observed elevated expression of IL‐1β in subjects with neutrophilic asthma. It has also been reported that the inhibition of NLRP3 prevents neutrophilia and decreases airway hyper‐responsiveness.34