ISG15 and colorectal carcinoma: The results summarized in Figure 2D and 2E demonstrate that ISG15 overexpression in CRC cells, similar to L1, could elevate the proliferation of cells under stress (in the absence of serum) (Figure 2D) and an increase in the motility of cells in the “scratch wound” experiment (Figure 2E), but to a lesser extent than L1 overexpression.