Mutation, genomic deletion of its locus at 3p21 or loss of BAP1 expression has been reported from various tumor types such as non-small cell lung cancer [8, 9], renal cell carcinoma [10–12], gall bladder cancer [13], mesothelioma [14, 15] and uveal melanoma [16–18], and has been linked to poor prognosis in most of them [13, 17, 19]. The gene discussed is BAP1; the disease is neoplasm.