We report consistent regression of orthotopic glioma in xenograft mouse models treated with EGFR806-CAR T cells, with an overall response comparable to other EGFR-directed CAR T cells (Erbitux-CAR, EGFRvIII-CAR, Nimotuzumab-CAR) on glioma xenografts [38, 40, 41]. Here, EGFR is linked to glioma.